I have been prescribed Xarelto® (rivaroxaban) to either treat DVT or PE, or prevent them from recurring

Are there any drug interactions with other medicines whilst taking Xarelto?

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

If you are taking:

  • Some medicines for fungal infections (e.g. fluconazole, itraconazole, voriconazole, posaconazole), unless they are only applied to the skin
  • Ketoconazole tablets (used to treat Cushing’s syndrome - when the body produces an excess of cortisol)
  • Some medicines for bacterial infections (e.g. clarithromycin, erythromycin)
  • Some anti-viral medicines for HIV / AIDS (e.g. ritonavir)
  • Other medicines to reduce blood clotting (e.g. enoxaparin, clopidogrel or vitamin K antagonists such as warfarin and acenocoumarol)
  • Anti-inflammatory and pain relieving medicines (e.g. naproxen or acetylsalicylic acid)
  • Dronedarone, a medicine to treat abnormal heart beat
  • Some medicines to treat depression (selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs))

If any of the above apply to you, tell your doctor before taking Xarelto, because the effect of Xarelto may be increased. Your doctor will decide, if you should be treated with this medicine and if you should be kept under closer observation. If your doctor thinks that you are at increased risk of developing stomach or bowel ulcers, he may also use a preventative ulcer treatment.

If you are taking:

  • Some medicines for treatment of epilepsy (phenytoin, carbamazepine, phenobarbital)
  • St John’s Wort (Hypericum perforatum), a herbal product used for depression
  • Rifampicin, an antibiotic

If any of the above apply to you, tell your doctor before taking Xarelto, because the effect of Xarelto may be reduced. Your doctor will decide, if you should be treated with Xarelto and if you should be kept under closer observation.

Pregnancy and breast-feeding

Do not take Xarelto if you are pregnant or breast-feeding. If there is a chance that you could become pregnant, use a reliable contraceptive while you are taking Xarelto. If you become pregnant while you are taking this medicine, tell your doctor immediately, who will decide how you should be treated.

Driving and using machinery

Xarelto may cause dizziness (common side effect) or fainting (uncommon side effect). You should not drive or use machines if you are affected by these symptoms.

To access the latest version of the Xarelto 2.5mg, 10mg and 15/20 mg Summary of Product Characteristics (SmPC) as well as Xarelto Patient Information Leaflet (PIL), please click on the following link eMC Widget

Report Possible Side Effects

This medicine is subject to additional monitoring. This will allow quick identification of new safety information.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google Play or Apple App Store.

You can also report side effects and quality complaints to Bayer Plc. Further information is available on the “contact” tab at www.bayer.co.uk.

By reporting side effects you can help provide more information on the safety of this medicine.